Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

   Ekaterina Smirnova, Emmanuelle Bignon ... Adam Ben-Shem
2. 1. Structural Biology and Molecular Biophysics

   Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

   Xiaoxuan Lin, Patrick R Haller ... Tobin R Sosnick

   Identification of Cl⁻-induced folding advances the field’s understanding of prestin’s unique voltage-sensing mechanism and its involvement in mammalian hearing sensation.
3. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

   Megan M Cullinan, Robert C Klipp ... John R Bankston

   A novel FRET approach suggests that the intracellular termini of acid-sensing ion channel 1a do not form a complex at rest requiring a new hypothesis for ASIC1a involvement in stroke.
4. 1. Structural Biology and Molecular Biophysics

   Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants

   Laura M. Chamness, Charles P. Kuntz ... Jonathan P. Schlebach
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The catalytic mechanism of the RNA methyltransferase METTL3

   Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Ga chaperone and GEF Ric-8A

   Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
7. 1. Structural Biology and Molecular Biophysics

   LRMP inhibits the cAMP-dependence of HCN4 channels by disrupting intramolecular signal transduction

   Colin H Peters, Rohit K Singh ... John R Bankston
8. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

   Bronwyn A Lucas, Benjamin A Himes, Nikolaus Grigorieff

   2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

   Daniyal Tariq, Nicole Maurici ... Brian R. Crane
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping the architecture of the initiating phosphoglycosyl transferase from S. enterica O-antigen biosynthesis in a liponanoparticle

    Greg J. Dodge, Alyssa J. Anderson ... Barbara Imperiali