8,893 results found
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-throughput imaging and quantitative analysis uncovers the nature of plasmid positioning by ParABS

    Robin Köhler, Eugen Kaganovitch, Seán M Murray
    The ParABS system positions plasmids precisely within the cell but just below the threshold for oscillatory dynamics.
    1. Computational and Systems Biology

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm, AnnSofi Sandberg ... Janne Lehtiö
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

    Michelle Hays, Janet M Young ... Harmit S Malik
    A novel assay to measure 2-micron stability together with a survey of natural variation among Saccharomyces cerevisiae strains reveals novel means by which yeasts can combat the parasitic 2-micron plasmids.
    1. Cell Biology
    2. Evolutionary Biology

    Chimeric origins of ochrophytes and haptophytes revealed through an ancient plastid proteome

    Richard G Dorrell, Gillian Gile ... Chris Bowler
    An in silico reconstruction of a chloroplast that existed hundreds of millions of years ago casts new insights in the evolutionary processes, endosymbioses and chimerism events that shape the origin of plastids.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

    Peter J Diebold, Felicia N New ... Ilana L Brito
    One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

    Erik Bakkeren, Joana Anuschka Herter ... Wolf-Dietrich Hardt
    Bacterial gut pathogens that invade into host tissues during infection can boost the spread and accumulation of plasmids over time by forming reservoirs containing these plasmids within host tissues.
    1. Medicine

    Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

    Wanxia Gai, Ze Zhou ... YM Dennis Lo
    Epigenetic determination of tissue of origin of genetically classified subsets of plasma DNA molecules enhances transplantation monitoring and cancer testing.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Collateral sensitivity associated with antibiotic resistance plasmids

    Cristina Herencias, Jerónimo Rodríguez-Beltrán ... Álvaro San Millán
    Acquisition of antibiotic resistance plasmids induces collateral sensitivity to clinically relevant antibiotics in Escherichia coli, paving the way for targeted 'anti-plasmid' therapies able to preferentially eliminate plasmid-carrying bacteria.
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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK

    William Matlock, Samuel Lipworth ... REHAB Consortium
    A geographically and temporally restricted genomic surveillance study concludes that Enterobacterales plasmid dissemination between human and non-human niches might be occurring at greater rates than previously estimated.
    1. Cell Biology

    Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

    Joseph A Giovinazzo, Russell P Thomson ... Ryan Schreiner
    Cytotoxicity associated with APOL1 renal-risk variants occurs through its plasma-membrane localization, where aberrant channel activity drives a sustained sodium and calcium influx leading to cell swelling and eventually cell death.

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