279 results found
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto, Branka Hrvoj-Mihic ... Fred H Gage
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Cell Biology
    2. Developmental Biology

    DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice

    Yi Tian Yap, Wei Li ... Zhibing Zhang
    Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.
    1. Cell Biology
    2. Neuroscience

    The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

    Jana Dorfman Marcette, Jessica Jie Chen, Michael L Nonet
    The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.
    1. Evolutionary Biology

    Spatio-temporal control of mutualism in legumes helps spread symbiotic nitrogen fixation

    Benoit Daubech, Philippe Remigi ... Delphine Capela
    Experiments and mathematical modelling show that rare nitrogen fixing symbionts invade a population dominated by non-fixing bacteria across plant generations, above a threshold of a combination of ecological factors.
    1. Cell Biology

    An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

    Marco Marchetti, Chenge Zhang, Bruce A Edgar
    An improved culture method for explanted adult Drosophila organs allows the live-imaging of damage response, cell differentiation, and tracing of progenitor cell lineages through multiple rounds of division.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

    Irene Gallego Romero, Bryan J Pavlovic ... Yoav Gilad
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
    1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission

    Jamie M Ellingford, Ryan George ... Graeme CM Black
    Characterisation of SARS-CoV-2 genomic divergence in healthcare-associated outbreaks demonstrates that the inclusion of healthcare workers in contact networks identifies additional links in SARS-CoV-2 transmission pathways.
    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.

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