Maria C Marchetto, Branka Hrvoj-Mihic ... Fred H Gage
Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.
Benoit Daubech, Philippe Remigi ... Delphine Capela
Experiments and mathematical modelling show that rare nitrogen fixing symbionts invade a population dominated by non-fixing bacteria across plant generations, above a threshold of a combination of ecological factors.
An improved culture method for explanted adult Drosophila organs allows the live-imaging of damage response, cell differentiation, and tracing of progenitor cell lineages through multiple rounds of division.
A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
Simon Schneider, Andjela Kovacevic ... Hubert Schorle
Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
Jamie M Ellingford, Ryan George ... Graeme CM Black
Characterisation of SARS-CoV-2 genomic divergence in healthcare-associated outbreaks demonstrates that the inclusion of healthcare workers in contact networks identifies additional links in SARS-CoV-2 transmission pathways.
The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.