163 results found
    1. Neuroscience

    The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx

    Luigi Prisco, Stephan Hubertus Deimel ... Gaia Tavosanis
    By participating in the microglomerular microcircuit in the Drosophila mushroom body calyx, the anterior paired lateral neuron normalizes odour-evoked representations at the calyx via inhibition proportional to the input strength and localized to the regions where those inputs are positioned.
    1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
    1. Neuroscience

    Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

    Yuji Okamoto, Noa Lipstein ... Mitsuharu Midorikawa
    Capacitance measurements and pH imaging reveal distinct modes of uptake for endocytotic presynaptic membrane and proteins.
    1. Cell Biology
    2. Neuroscience

    Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model

    Tetsuya Hori, Kohgaku Eguchi ... Tomoyuki Takahashi
    Wild-type human recombinant tau protein infused in presynaptic terminals newly assembled microtubules, which sequestered cytosolic dynamins, thereby blocking synaptic vesicle endocytosis and causing activity-dependent rundown of excitatory synaptic transmission in a slice model of mouse brainstem.
    1. Neuroscience

    Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

    Amy Richardson, Victoria Ciampani ... Ian D Forsythe
    The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory responses of Drosophila are encoded in the organization of projection neurons

    Kiri Choi, Won Kyu Kim, Changbong Hyeon
    The organization of olfactory projection neurons and their synaptic connectivity with third-order neurons studied along with olfactory responses suggest that the labeled-line design is partially at work in the Drosophila olfactory system.
    1. Neuroscience

    Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

    Özgür Genç, Olexiy Kochubey ... Ralf Schneggenburger
    Protein kinase C brings about post-tetanic potentiation - a temporary increase in synaptic strength due to increased transmitter release - via phosphorylation of a target protein, Munc18-1.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert, R Oliver Goral ... Samuel M Young Jr
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.
    1. Neuroscience

    RETRACTED: Protein kinase C is a calcium sensor for presynaptic short-term plasticity

    Diasynou Fioravante, YunXiang Chu ... Wade G Regehr
    Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.

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