172 results found
    1. Neuroscience

    A mechanistic insight into sources of error of visual working memory in multiple sclerosis

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Imprecision in decoding information and swap error, that is, mistakenly reporting a non-target feature, contributes to working memory deficit in the multiple sclerosis population.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

    Wenfei Pan, Vladimir A Meshcheryakov ... Vivien Ya-Fan Wang
    Structural and biophysical characterization of NF-κB p52 in complex with closely related DNAs reveals the dynamic states of central base pair(s) have a strong influence on transcriptional activity of p52.
    1. Neuroscience

    Successful retrieval of competing spatial environments in humans involves hippocampal pattern separation mechanisms

    Colin T Kyle, Jared D Stokes ... Arne D Ekstrom
    Functional magnetic resonance imaging and multivariate pattern analysis reveal remapping-like behavior during successful retrieval of competing environments, while unsuccessful retrieval is accompanied by reinstatement of interfering representations.
    1. Neuroscience

    A dynamic neural resource model bridges sensory and working memory

    Ivan Tomić, Paul M. Bays
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

    Karthikeyani Chellappa, Poonamjot Deol ... Frances M Sladek
    Proper gut health depends on the balance between two naturally occurring variants of a transcription factor in the colon.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of human TERT elements necessary for telomerase recruitment to telomeres

    Jens C Schmidt, Andrew B Dalby, Thomas R Cech
    The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu, Nicolas Basty ... Madeleine Cule
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Plant Biology

    LPCAT1 controls phosphate homeostasis in a zinc-dependent manner

    Mushtak Kisko, Nadia Bouain ... Hatem Rouached
    Phosphate accumulation in zinc-deficient Arabidobsis shoots is regulated by a pathway involving the transcription factor bZIP23, the phospholipid-remodelling enzyme LPCAT1 and the transporter PHT1;1.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An elusive electron shuttle from a facultative anaerobe

    Emily Mevers, Lin Su ... Jon Clardy
    The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
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    1. Cell Biology

    Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

    S Zachary Swartz, Hieu T Nguyen ... Arminja N Kettenbach
    Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.

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