42 results found
    1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Colicin E1 opens its hinge to plug TolC

    S Jimmy Budiardjo, Jacqueline J Stevens ... Joanna SG Slusky
    Bacterial warfare protein colicin E1 opens its hinge to plug antibiotic efflux pump TolC and potentiate antibiotics.
    1. Microbiology and Infectious Disease

    Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

    Daan F van den Berg, Baltus A van der Steen ... Stan JJ Brouns
    A new perspective on the 50-year old mystery of why phages encode their own tRNAs.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Ecology

    ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles

    Anja S Strauss, Sven Peters ... Antje Burse
    A transport protein enables leaf beetle larvae to take up and store plant toxins and use them as part of their own defense strategy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

    Annah S Rolig, Emily Goers Sweeney ... Karen Guillemin
    Discovery of a secreted protein from resident gut bacteria that reduced intestinal innate immune responses which would otherwise simultaneously compromise both bacterial and host survival.
    1. Ecology
    2. Evolutionary Biology

    The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics

    Rene Niehus, Nuno M Oliveira ... Kevin R Foster
    Evolutionary game theory identifies reciprocation as a key winning strategy for warring bacteria.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

    Yoseop Yoon, Jeff Klomp ... Urs Schmidt-Ott
    Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bile salt receptor complex activates a pathogenic type III secretion system

    Peng Li, Giomar Rivera-Cancel ... Kim Orth
    Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.
    1. Microbiology and Infectious Disease

    Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

    Cassandra Koh, Lionel Frangeul ... Maria-Carla Saleh
    A score-based read selection strategy enables the assembly of novel full-length ribosomal RNA sequences for mosquitoes, which improves the physical and computational removal of interfering ribosomal RNA reads in RNA-seq and provides another molecular marker for taxonomic and phylogenetic inquiries.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson, John William Young ... Franck Duong
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.

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