17,601 results found
    1. Chromosomes and Gene Expression

    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

    Yi-Jun Sheu, Risa Karakida Kawaguchi ... Bruce Stillman
    The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.
    1. Neuroscience

    Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors

    Flavia P Franco, Pingxi Xu ... Walter S Leal
    The southern house mosquito senses the oviposition attractants skatole and indole with two receptor proteins sharing only 50% amino acid identity, and having the residues alanine-73 and leucine-74 in the skatole and indole receptors, respectively, control their specificity.
    1. Medicine

    Is calcium a link between inflammatory bone resorption and heart disease?

    Gordon L Klein
    A mechanism is proposed that allows investigators to study interventions to delay onset of heart disease in patients suffering from chronic inflammatory disease with bone loss.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

    Anne-Claire Godet, Emilie Roussel ... Anne-Catherine Prats
    LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys, Anne-Claire Godet ... Anne-Catherine Prats
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.
    1. Neuroscience

    Thalamocortical contributions to cognitive task activity

    Kai Hwang, James M Shine ... Evan Sorenson
    Human thalamic activity transformed via thalamocortical functional connectivity to support task representations across functional domains.
    1. Neuroscience

    Neuropsychological evidence of multi-domain network hubs in the human thalamus

    Kai Hwang, James M Shine ... Aaron Boes
    Lesions to the anterior-medio-dorsal thalamus cause widespread behavioral impairments across multiple cognitive domains, suggesting that thalamic hubs are critical for interconnecting diverse cognitive processes.
    1. Cell Biology
    2. Developmental Biology

    Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation

    Katrina M Longhini, Michael Glotzer
    Centrosomal Aurora A (AIR-1), together with cortical actomyosin flows, induces polarization of ECT-2, the activator of RHO-1, during polarization and cytokinesis, in order to promote furrow formation.
    1. Cell Biology

    Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

    Xiaoqin Fu, Lu Rao ... Judy Shih-Hwa Liu
    DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
    1. Neuroscience

    Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making

    Claire A Symanski, John H Bladon ... Shantanu P Jadhav
    A novel mechanism of long-range coordination mediated by beta oscillations across sensory and cognitive netowrks for utilization of odor-cued associations and translating them into decisions.

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