Cell Biology

Latest articles

1. 1. Cell Biology

   Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

   Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry

   Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
2. 1. Cell Biology

   Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

   Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer

   Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
3. 1. Cell Biology

   Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

   Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu

   In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
4. 1. Cell Biology

   Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

   Edward M. Germany, Nakajohn Thewasano ... Takuya Shiota
5. 1. Cell Biology

   Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

   Samarpan Maiti, Kaushik Bhattacharya ... Didier Picard

   Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
6. 1. Cell Biology
   2. Immunology and Inflammation

   DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress

   Fabian Hersperger, Tim Meyring ... Katrin Kierdorf
7. 1. Cell Biology

   Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function

   Rita De Gasperi, Laszlo Csernoch ... Christopher P. Cardozo
8. 1. Cancer Biology
   2. Cell Biology

   mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3^IBTK-mediated non-degradative ubiquitination of eIF4A1

   Huiru Sun, Dongyue Jiao ... Chenji Wang
9. 1. Cell Biology
   2. Computational and Systems Biology

   Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies

   Thomas Grandits, Christoph M. Augustin ... Alexander Jung
10. 1. Cell Biology

    Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis

    Serena Janho dit Hreich, Thierry Juhel ... Valérie Vouret-Craviari